Afatinib BIBW2992 Intermediate3

CAS NO.:314771-88-5

Molecular Formula:C₁₈H₁₄N₄O₄FCl

Molecular Weight:404.77956

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.

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