AZD3759

CAS NO.:1626387-80-1

Molecular Formula:C₂₂H₂₃ClFN₅O₃

Molecular Weight:459.901127099991

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

AZD3759 is a potent, oral active, central nervous system-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50 values were 0.3, 0.2, and 0.2 nM for EGFR TK wild-type, L858R mutant, and Exon 19Del enzymes, respectively. IC50 value: 7.2 nM (L858R pEGFR).

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Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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