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BAY 61-3606 dihydrochloride

Catalog No.: R11585
CAS No.: 648903-57-5
Formula: C20H18N6O3.2[HCl]
Weight: 463.3172
Details:
Theoretical analysis

CAS NO.:648903-57-5

Molecular Formula:C20H18N6O3.2[HCl]

Molecular Weight:463.3172

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.
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Packing: 10mg/50mg/100mg/500mg/1g and we provide a variety of packaging.

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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

Product will be shipped with supporting analytical data.

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