Hydroxythiohomosildenafil

CAS NO.:479073-82-0

Molecular Formula:C₂₃H₃₂N₆O₄S₂

Molecular Weight:520.66798

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Hydroxythiohomo Sildenafil is a thio analog of Sildenafil which has been reported to be a PDE5 inhibitor. Sildenafil is a selective inhibitor of type 5 cGMP phosphodiesterase (PDE5), which catalyzes teh hydrolysis of cGMP, an important secondary messenger molecule in a variety of cellular processes. Sildenafil has been reported to enhance angiogenesis in rat models of stroke and also has been reported to be a mild vasodilator. Sildenafil has been shown to prevent indomethacin-induced small intestinal ulceration formation throuh an NO/cGMP-dependent mechanism.

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