R10065 |
Losartan potassium |
Losartan is an angiotensin II receptor antagonist, competes with the binding of
|
R10066 |
Dapagliflozin; BMS512148 |
Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, ex
|
R10068 |
GSK1120212; Trametinib; JTP74057 |
Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC
|
R10071 |
SRT1720 HCl |
SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay
|
R10072 |
GSK690693 |
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM
|
R10073 |
Apitolisib (Synonyms: GDC-0980; GNE 390; RG 7422) |
Apitolisib (GDC-0980, RG7422) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/
|
R10074 |
AZ628 |
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 1
|
R10075 |
Apalutamide (ARN-509) |
ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of
|
R10076 |
Crizotinib (PF-02341066) |
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11
|
R10077 |
AMG208 |
AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.
|
R10078 |
EMD1214063 |
Tepotinib (EMD 1214063) is a potent and selective c-Met inhibitor with IC50 of 4
|
R10079 |
GSK2636771 |
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitiv
|
R10080 |
TH-302 |
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid
|
R10081 |
TAS103 dihydrochloride |
TAS-103 2Hcl(BMS-247615 2Hcl) is a dual inhibitor of topoisomerase-I (topo-I) an
|
R10082 |
Palomid 529; P529 |
Palomid 529 (P529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosph
|
R10083 |
XL413 Hydrochloride |
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7
|
R10084 |
Orteronel; TAK-700 |
Orteronel(TAK-700) was selected as a candidate for clinical evaluation. orterone
|
R10085 |
KU-55933 |
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50
|
R10086 |
BAY571293 |
Pritelivir (BAY 57-1293) is a potent helicase primase inhibitor, exhibiting anti
|
R10087 |
AZD9291 |
Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibi
|
R10088 |
RTA408; Omaveloxolone |
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprote
|
R10090 |
AZD5438 |
AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-
|
R10091 |
LCZ696;Sacubitril;Valsartan |
Varespladib (LY315920) is a potent and selective human non-pancreatic secretory
|
R10092 |
TWS11 |
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of
|
R10093 |
VU0364439 |
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
|