R10094 |
RITA (NSC652287) |
RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detec
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R10095 |
Tenovin1 |
Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquit
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R10096 |
IOX2 |
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21
|
R10097 |
GNF-2 |
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no a
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R10100 |
GSK2646264A |
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R10101 |
Telaprevir (VX-950) |
Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35
|
R10102 |
AKR501 |
Avatrombopag(AKR-501; AS1670542) is a novel orally-active thrombopoietin(TPO) re
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R10104 |
PF03814735 |
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50o
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R10105 |
Nelfinavir |
Nelfinavir(AG-1341) is a potent and orally bioavailable human immunodeficiency v
|
R10107 |
NVPBKM120 |
BKM120 (NVP-BKM120, Buparlisib) is a selective PI3K inhibitor of p110α/β/δ/γ wit
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R10108 |
Olaparib (Synonyms: AZD2281; KU0059436) |
Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5
|
R10109 |
VX661 |
VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein r
|
R10110 |
LCZ696;Sacubitril/Valsartan |
LCZ696, consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally
|
R10111 |
Enzalutamide; MDV3100 |
Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 n
|
R10112 |
Abiraterone Acetate; CB7630 |
Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal
|
R10113 |
Abiraterone; CB7598 |
Abiraterone is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay.
|
R10118 |
Regorafenib; BAY73-4506; BAY734506 |
Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3
|
R10119 |
PAC-1 (Synonyms: Procaspase activating compound 1) |
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM and the first smal
|
R10121 |
Bortezomib (Synonyms: PS-341; LDP-341; NSC 681239) |
Bortezomib (PS-341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM in a
|
R10122 |
Nitisinone |
Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxyge
|
R10123 |
Bosetan |
Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of
|
R10124 |
Ibrutinib;PCI-32765 |
Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (
|
R10125 |
TOK001; VN1241 |
Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist
|
R10126 |
WZ4002 |
WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with
|
R10127 |
Linifanib (Synonyms: ABT-869; AL-39324) |
Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for
|