R10007 |
AZD6244 |
Selumetinib (AZD6244) is a potent, highly selective MEK1 inhibitor with IC50 of
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R10031 |
BIIB-024; MLN2480 |
MLN2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in chinical tri
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R10068 |
GSK1120212; Trametinib; JTP74057 |
Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC
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R10074 |
AZ628 |
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 1
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R10190 |
BIX02188 |
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK
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R10216 |
PLX4032 |
Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with
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R10250 |
TAK632 |
TAK-632 is a potent pan-Raf inhibitor with IC50 of 8.3 nM and 1.4 nM for B-Raf(w
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R10412 |
Vemurafenib (PLX4032, RG7204) |
Vemurafenib (PLX4032, RG7204) is a novel and potent inhibitor of B-RafV600E with
|
R10680 |
ZM336372 |
ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold
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R10829 |
SCH772984 |
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM in
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R10934 |
BI-847325 |
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibi
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R10942 |
Binimetinib; MEK162,ARRY-162,ARRY-438162 |
Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with
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R10952 |
Cobimetinib;GDC-0973; XL518 |
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor w
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R11503 |
Dabrafenib (GSK2118436) |
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8
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R11507 |
BMS-582949;BMS582949 |
BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 M
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R11583 |
Ravoxertinib (GDC-0994) |
GDC-0994 is a potent, orally available ERK1/2 inhibitor with IC50
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R11586 |
DEL-22379;DEL22379 |
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.
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R2032487 |
PD318088 |
PD318088 is an allosteric MEK inhibitor.
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R2032746 |
GDC-0879 |
GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.
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